EBM is Broken

1. Cautionary Tales – South Pole Race: When Limeys Get Scurvy.

2. Problems in the "evidence" of "evidence-based medicine"

3. Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality

4. Why Most Published Research Findings Are False

5. A Decade of Reversal: An Analysis of 146 Contradicted Medical Practices

6. Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

7. Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

8. Empagliflozin in Heart Failure with a Preserved Ejection Fraction

9. Once-Weekly Semaglutide in Adolescents with Obesity

10. Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study

11. Comparison of Evidence of Treatment Effects in Randomized and Nonrandomized Studies

12. Can the Learning Health Care System Be Educated With Observational Data?

13. Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey

14. Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease: The PRECISE Randomized Clinical Trial

15. How evidence-based medicine is failing due to biased trials and selective publication. Journal of Evaluation in Clinical Practice. 2014; 20: 908-914.

16. Comorbidity and multimorbidity need to be placed in the context of a framework of risk, responsiveness, and vulnerability. Journal of Clinical Epidemiology. 2014:67:244-246. 

17. The clinical inadequacy of evidence-based medicine and the need for conceptual framework based on clinical judgement. Psychotherapy and Psychosomatics. 2015; 84: 1-3.

18. Evidence-based medicine has been hijacked: a report to David Sackett. Journal of Clinical Epidemiology, 2016; 73: 82-86.

19. Evidence-based medicine was bound to fail: a report to Alvan Feinstein. Journal of Clinical Epidemiology. 2017; 84: 3-7.

20. P-values and significance: The null hypothesis that they are not related is correct. Journal of Critical Care. 2019; 54:159–162

21. The limitations of evidence-based medicine compel the practice of personalized medicine. Intensive Care Med. 2024; 50:1323–1326

22. Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

23. Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo — The Cardiac Arrhythmia Suppression Trial (CAST trial)

24. Evidence-Based Medicine: A New Approach to Teaching the Practice of Medicine

25. Seven alternatives to evidence based medicine